GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine.
- Composed of 3 amino acids (Gly-His-Lys) + copper ion (Cu²⁺)
- First identified in 1973 by Dr. Loren Pickart
- Plays a major role in tissue repair, skin regeneration, and gene signaling
👉 In simple terms:
GHK-Cu is a natural “repair signal” peptide that delivers copper to tissues and helps activate healing, collagen production, and regeneration.
Features
1. Copper-Binding Repair Signal (Core Feature)
- Strongly binds copper ions and transports them to cells
- Copper acts as a cofactor for enzymes involved in healing
👉 This is the foundation of its biological activity.
2. Powerful Skin Regeneration Effects
- Stimulates collagen and elastin production
- Improves:
- Skin firmness
- Elasticity
- Texture
- Studies show significant increases in collagen synthesis
3. Broad Gene Regulation
- Influences thousands of genes (4,000+) related to:
- Tissue repair
- Anti-inflammatory pathways
- Antioxidant defense
👉 This makes it far more than just a “cosmetic peptide.”
4. Wound Healing & Tissue Repair
- Promotes:
- Fibroblast activation
- Angiogenesis (new blood vessel formation)
- Extracellular matrix remodeling
👉 Used in research for skin healing, scar reduction, and tissue regeneration.






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